Raj B, Wagner DW, McKenna A, Pandey S, Klein AM, Shendure J, Gagnon JA*, Schier AF*. Nature Biotechnology, 2018. *co-corresponding authors
We merged single cell RNA sequencing with CRISPR-Cas lineage tracing to determine relationships between cells in a large single cell atlas of the juvenile zebrafish brain.
Gagnon JA, Obbad K, Schier AF. Development, 2018.
We discovered that the transcription factor Nanog is required primarily for extraembryonic tissue development, and is not required in embryonic or germ cells.
McKenna A*, Findlay G*, Gagnon JA*, Horwitz M, Schier AF, Shendure J. Science, 2016. * co-first authors
We developed GESTALT - a tool for lineage tracing in animals using CRISPR-Cas genome editing.
Gagnon JA, Valen E, Thyme SB, Huang P, Akhmetova L, Pauli A, Montague TG, Zimmerman S, Richter C, Schier AF. PLoS One, 2014.
We determined rules that increase CRISPR-Cas activity in zebrafish, and found biases in DNA repair outcomes.